Endocrine Abstracts

Introduction: There are several endocrine causes of hyponatremia. SIADH is perhaps the most challenging, as patients do not always respond to initial correction measures and pharmacological treatment options are scarce. Urea is a viable option, but not commonly used.Methods: Analysis of patients with SIADH-induced hyponatremia (<135mEq/l) treated with urea per os in the Portuguese Institute of Oncology of Porto between August 2021 and Octobe...

Introduction: Nonislet cell tumour hypoglycemia (NICTH) is a rare complication of malignancy. The most common cause is overproduction of IGF2, which activates insulin receptors, resulting in hypoinsulinemic hypoglycemia. When a solitary fibrous tumor is responsible, it is called Doege-Potter syndrome.Case 1: 58-year-old woman, with a history of gastrointestinal stromal tumor and pleural solitary fibrous tumor with pulmonary and lymph node metastases. She...

Introduction: Bilateral adrenal masses may appear in the context of metastatic disease, adrenal congenital hyperplasia, primary tumors or infections, among others. Primary adrenal lymphoma is rare, accounting for approximately 1% of cases of non-Hodgkin lymphoma. Clinical case: 47-year-old woman, with a history of erythema nodosum and left hemithyroidectomy in the context of benign nodular disease. She presented with persistent fever and tiredne...

Introduction: Hypopituitarism is a rare diagnosis that is mainly due to primary pituitary neoplasms and their treatment. There are rarer causes such as hemorrhage/ischemia, traumatic brain injury, infections and infiltrative lesions. Clinical case: We herein present an 18-year-old male patient diagnosed with acute promyelocytic leukemia at the age of 14, with no evidence of central nervous system invasion in several lumbar punctures during his follow-up....

Introduction: Incidence of Digestive NETs (DNETs) has increased in the last 40 years. Visceral obesity, metabolic syndrome (MetS) and insulin resistance (IR) have been associated with several types of cancer.Aim: To evaluate possible associations of obesity, hyperinsulinemia and IR with well-differentiated (WD) DNETs through a case control study.Materials and methods: Ninety-six patients with gastrointestinal (75.0%) and pNET (22.9...

Topiramate (TPM) is an anticonvulsant drug used for the treatment of epilepsy and prophylaxis of migraine. Weight loss is a side effect frequently reported in patients and animal models treated with TPM. Some studies showed that TPM may decrease energy storage, and thus increase energy expenditure and thermogenesis. However, the mechanisms by which TPM reduces body weight are not completely understood. Anorexigenic hormones such as insulin and leptin regulate the activity of d...

Introduction: Hyperthyroidism is an endocrine condition with multiple causes. Paraneoplastic hyperthyroidism due to marked overproduction of human chorionic gonadotropin (hCG) by choriocarcinoma is a rare diagnosis, which results from the homology of the alpha subunit of hCG to TSH.Clinical case: A 33-year-old man, with a history of cryptorchidism and orchidopexy in infancy and a euthyroid thyroid nodule, presented with nausea, constipation, and abdomina...